The Group

We’re recruiting …

We moved to St. Andrews University in August 2015 and are busy recruiting to the post-doctoral, technician and studentship positions we have available. This page will be automagically updated as these appointments are made. If you are interested in joining the group please contact us. Studentship positions are advertised on findaphd.com and other posts will be advertised on jobs.ac.uk.

Prof David Evans
Evans, Prof David: [Group PI] Professor

tel: 01334 46 3396
fax:
room: 2.11
email: dje2@st-andrews.ac.uk
Prof David Evans
Biomolecular Sciences Building
University of St Andrews
North Haugh
St Andrews
KY16 9ST
Fife
UK


Related Content:

research@st-andrews
Biology Management Group
Biology Research Committee
School of Biology
Biomedical Sciences Research Complex

Symbiosis Profile Page
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I am a virologist studying the biology of single stranded positive sense RNA viruses, including poliovirus, hepatitis C virus and deformed wing virus of honeybees. My current research focuses on the evolution, replication and pathogenesis of these viruses. 

Poliovirus no longer causes significant human mortality but is an exceptionally well characterised virus we use to study the molecular mechanism of recombination, an important evolutionary process exhibited by many other single stranded postiive sense RNA viruses. Our recent studies have demonstrated that recombination is a biphasic process, involving both a strand exchange recombination event and a secondary resolution event. The characteristics of intermediates in this event may explain 'evolution by duplication' in RNA viruses, in which partial regions of the genome become duplicated and then evolve independently.

Deformed wing virus (DWV) is the most important virus infecting honeybees and is responsible for the majority of overwintering colony losses. DWV is transmitted during feeding by the ectoparasitic mite Varroa to developing honeybee pupae. We have shown that mite-exposed pupae contain a near-clonal population of DWV present at very high levels. In contrast, pupae that have not been exposed to mites contain a low level of a highly diverse DWV population. We are currently investigating the molecular pathogenesis of the virulent strain of DWV and developing strategies to control the virus. 

[source: research@st-andrews]

We study the biology of a range of viruses with single stranded, positive sense RNA genomes that are of medical importance, that provide tractable model systems or that are important in food security. Our current research focuses on the replication and evolution of poliovirus and the biology of deformed wing virus of honeybees.

[source: Symbiosis]

Recent Publications:

Recent publications


5  (of 5 published available) for dje2 with keyword NDAS clear keyword filter. (source: University of St Andrews PURE)
Please click title of any item for full details.

2018 (5)
ISME Journal
vol.12 pp.1273-1286
(Article)
Energy limitation of cyanophage development
Richard J. Puxty, David John Evans, Andrew D. Millard, David J. Scanlan 
Keywords: Microbiology, Ecology, Evolution, Behavior and Systematics
2017 (29/9)
eLife
vol.6 
(Article)
CpG and UpA dinucleotides in both coding and non-coding regions of echovirus 7 inhibit replication initiation post-entry
Jelke J. Fros, Isabelle Dietrich, Kinda Alshaikhahmed, Tim C. Passchier, David John Evans, Peter Simmonds 
2016 (19/8)
Nucleic Acids Research
vol.44 pp.6883-6895
(Article)
2016 (20/6)
Current Biology
vol.26 pp.1585-1589
(Article)
Viruses inhibit CO2 fixation in the most abundant phototrophs on Earth
Richard J. Puxty, Andrew D. Millard, David John Evans, David J. Scanlan 
2015 (14/7)
Proceedings of the National Academy of Sciences of the United States of America
vol.112 pp.E3633-E3634
(Letter)

[hide]
Bentley, Dr Kirsten: Research Fellow

tel:
fax:
room:
email: kb209@st-andrews.ac.uk
Dr Kirsten Bentley
Biomolecular Sciences Building
University of St Andrews
North Haugh
St Andrews
KY16 9ST
Fife
UK


Related Content:

research@st-andrews
School of Biology

Symbiosis Profile Page
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[source: research@st-andrews]

Recent Publications:

Recent publications


1  (of 1 published available) for kb209 with keyword NDAS clear keyword filter. (source: University of St Andrews PURE)
Please click title of any item for full details.

2017 (24/7)
Virology Journal
vol.14 
(Article)
Unexpected complexity in the interference activity of a cloned influenza defective interfering RNA
Bo Meng, Kirsten Bentley, Anthony C. Marriott, Paul D. Scott, Nigel J. Dimmock, Andrew J Easton 
Keywords: Influenza virus, Defective interfering RNA, Replication, Interference

[hide]
Pearson, Mr Ashley: Technician

tel: 01334 464801
fax:
room:
email: ajp20@st-andrews.ac.uk
Mr Ashley Pearson
Biomedical Sciences Building
University of St Andrews
North Haugh
St Andrews
KY16 9ST
Fife
UK


Related Content:

research@st-andrews
School of Biology
Biomedical Sciences Research Complex
Biology Equality and Diversity Committee

Symbiosis Profile Page
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[source: research@st-andrews]

Recent Publications:

Data could not be retrieved from PURE at this time. (research-outputs/persons)[hide]

 

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