The Group

We’re recruiting …

We moved to St. Andrews University in August 2015 and are busy recruiting to the post-doctoral, technician and studentship positions we have available. This page will be automagically updated as these appointments are made. If you are interested in joining the group please contact us. Studentship positions are advertised on findaphd.com and other posts will be advertised on jobs.ac.uk.

Prof David Evans
Evans, Prof David: [Group PI] Professor

tel: 01334 46 3396
fax:
room: 2.11
email: dje2@st-andrews.ac.uk
Prof David Evans
Biomolecular Sciences Building
University of St Andrews
North Haugh
St Andrews
KY16 9ST
Fife
UK


Related Content:

research@st-andrews
Biology Management Group
Biology Research Committee
School of Biology
Biomedical Sciences Research Complex

Symbiosis Profile Page
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I am a virologist studying the biology of single stranded positive sense RNA viruses, including poliovirus, hepatitis C virus and deformed wing virus of honeybees. My current research focuses on the evolution, replication and pathogenesis of these viruses. 

Poliovirus no longer causes significant human mortality but is an exceptionally well characterised virus we use to study the molecular mechanism of recombination, an important evolutionary process exhibited by many other single stranded postiive sense RNA viruses. Our recent studies have demonstrated that recombination is a biphasic process, involving both a strand exchange recombination event and a secondary resolution event. The characteristics of intermediates in this event may explain 'evolution by duplication' in RNA viruses, in which partial regions of the genome become duplicated and then evolve independently.

Deformed wing virus (DWV) is the most important virus infecting honeybees and is responsible for the majority of overwintering colony losses. DWV is transmitted during feeding by the ectoparasitic mite Varroa to developing honeybee pupae. We have shown that mite-exposed pupae contain a near-clonal population of DWV present at very high levels. In contrast, pupae that have not been exposed to mites contain a low level of a highly diverse DWV population. We are currently investigating the molecular pathogenesis of the virulent strain of DWV and developing strategies to control the virus. 

[source: research@st-andrews]

We study the biology of a range of viruses with single stranded, positive sense RNA genomes that are of medical importance, that provide tractable model systems or that are important in food security. Our current research focuses on the replication and evolution of poliovirus and the biology of deformed wing virus of honeybees.

[source: Symbiosis]

Recent Publications:

5 (of 77 published available) for dje2 (source: University of St Andrews PURE)
Please click title of any item for full details

Energy limitation of cyanophage development Richard J. Puxty, David John Evans, Andrew D. Millard, David J. Scanlan
ISME Journal 2018 vol.12 pp.1273-1286
Mechanisms and consequences of positive-strand RNA virus recombination Kirsten Bentley, David John Evans
Journal of General Virology 2018 vol.99 pp.1345-1356
CpG and UpA dinucleotides in both coding and non-coding regions of echovirus 7 inhibit replication initiation post-entry Jelke J. Fros, Isabelle Dietrich, Kinda Alshaikhahmed, Tim C. Passchier, David John Evans, Peter Simmonds
eLife 2017 vol.6
Biochemical and genetic analysis of the role of the viral polymerase in enterovirus recombination Andrew Woodman, Jamie Arnold, Craig Cameron, David John Evans
Nucleic Acids Research 2016 vol.44 pp.6883-6895

[hide]
Bentley, Dr Kirsten: Research Fellow

tel:
fax:
room:
email: kb209@st-andrews.ac.uk
Dr Kirsten Bentley
Biomolecular Sciences Building
University of St Andrews
North Haugh
St Andrews
KY16 9ST
Fife
UK


Related Content:

research@st-andrews
School of Biology

Symbiosis Profile Page
edit kb209 details

[source: research@st-andrews]

Recent Publications:

5 (of 8 published available) for kb209 (source: University of St Andrews PURE)
Please click title of any item for full details

Mechanisms and consequences of positive-strand RNA virus recombination Kirsten Bentley, David John Evans
Journal of General Virology 2018 vol.99 pp.1345-1356
Unexpected complexity in the interference activity of a cloned influenza defective interfering RNA Bo Meng, Kirsten Bentley, Anthony C. Marriott, Paul D. Scott, Nigel J. Dimmock, Andrew J Easton
Virology Journal 2017 vol.14
Inhibition of HCV translation by disrupting the structure and interactions of the viral CRE and 3' X-tail Andrew Tuplin, Madeleine Struthers, Jonathan Cook, Kirsten Bentley, David John Evans
Nucleic Acids Research 2015 vol.43 pp.2914-2926
Identification of a noncanonically transcribed subgenomic mRNA of infectious bronchitis virus and other gammacoronaviruses Kirsten Bentley, Sarah May Keep, Maria Armesto, Paul Britton
Journal of Virology 2013 vol.87 pp.2128-36

[hide]
Pearson, Mr Ashley: Technician

tel: 01334 463398
fax:
room:
email: ajp20@st-andrews.ac.uk
Mr Ashley Pearson
Biomedical Sciences Building
University of St Andrews
North Haugh
St Andrews
KY16 9ST
Fife
UK


Related Content:

research@st-andrews
School of Biology
Biomedical Sciences Research Complex
Biology Equality and Diversity Committee

Symbiosis Profile Page
edit ajp20 details
Data from research@st-andrews is not currently available for ajp20.

[source: research@st-andrews]

Recent Publications:

Data could not be retrieved from PURE at this time. (research-outputs/persons)[hide]

 

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