The Group

We’re recruiting …

We moved to St. Andrews University in August 2015 and are busy recruiting to the post-doctoral, technician and studentship positions we have available. This page will be automagically updated as these appointments are made. If you are interested in joining the group please contact us. Studentship positions are advertised on findaphd.com and other posts will be advertised on jobs.ac.uk.

Prof David Evans
Evans, Prof David: [Group PI] Professor

tel: 01334 46 3396
fax:
room: 2.11
email: dje2@st-andrews.ac.uk
Prof David Evans
Biomolecular Sciences Building
University of St Andrews
North Haugh
St Andrews
KY16 9ST
Fife
UK


Related Content:

research@st-andrews
Biology Management Group
Biology Research Committee
School of Biology
Biomedical Sciences Research Complex

Symbiosis Profile Page
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I am a virologist studying the biology of single stranded positive sense RNA viruses, including poliovirus, hepatitis C virus and deformed wing virus of honeybees. My current research focuses on the evolution, replication and pathogenesis of these viruses. 

Poliovirus no longer causes significant human mortality but is an exceptionally well characterised virus we use to study the molecular mechanism of recombination, an important evolutionary process exhibited by many other single stranded postiive sense RNA viruses. Our recent studies have demonstrated that recombination is a biphasic process, involving both a strand exchange recombination event and a secondary resolution event. The characteristics of intermediates in this event may explain 'evolution by duplication' in RNA viruses, in which partial regions of the genome become duplicated and then evolve independently.

Deformed wing virus (DWV) is the most important virus infecting honeybees and is responsible for the majority of overwintering colony losses. DWV is transmitted during feeding by the ectoparasitic mite Varroa to developing honeybee pupae. We have shown that mite-exposed pupae contain a near-clonal population of DWV present at very high levels. In contrast, pupae that have not been exposed to mites contain a low level of a highly diverse DWV population. We are currently investigating the molecular pathogenesis of the virulent strain of DWV and developing strategies to control the virus. 

[source: research@st-andrews]

We study the biology of a range of viruses with single stranded, positive sense RNA genomes that are of medical importance, that provide tractable model systems or that are important in food security. Our current research focuses on the replication and evolution of poliovirus and the biology of deformed wing virus of honeybees.

[source: Symbiosis]

Recent Publications:

Recent publications


5  (of 77 published available) for dje2. (source: University of St Andrews PURE)
Please click title of any item for full details.

2018 (5)
ISME Journal
vol.12 pp.1273-1286
(Article)
Energy limitation of cyanophage development
Richard J. Puxty, David John Evans, Andrew D. Millard, David J. Scanlan 
Keywords: QR MicrobiologyMicrobiology, Ecology, Evolution, Behavior and SystematicsNDAS
2018 (1/10)
Journal of General Virology
vol.99 pp.1345-1356
(Review article)
2017 (29/9)
eLife
vol.6 
(Article)
CpG and UpA dinucleotides in both coding and non-coding regions of echovirus 7 inhibit replication initiation post-entry
Jelke J. Fros, Isabelle Dietrich, Kinda Alshaikhahmed, Tim C. Passchier, David John Evans, Peter Simmonds 
Keywords: QR355 Virology, RC Internal medicineNDAS
2016 (19/8)
Nucleic Acids Research
vol.44 pp.6883-6895
(Article)

[hide]
Bentley, Dr Kirsten: Research Fellow

tel:
fax:
room:
email: kb209@st-andrews.ac.uk
Dr Kirsten Bentley
Biomolecular Sciences Building
University of St Andrews
North Haugh
St Andrews
KY16 9ST
Fife
UK


Related Content:

research@st-andrews
School of Biology

Symbiosis Profile Page
edit kb209 details

[source: research@st-andrews]

Recent Publications:

Recent publications


5  (of 8 published available) for kb209. (source: University of St Andrews PURE)
Please click title of any item for full details.

2018 (1/10)
Journal of General Virology
vol.99 pp.1345-1356
(Review article)
2017 (24/7)
Virology Journal
vol.14 
(Article)
2015 (11/3)
Nucleic Acids Research
vol.43 pp.2914-2926
(Article)

[hide]
Gusachenko, Dr Alex: Research Fellow

tel:
fax:
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email: og21@st-andrews.ac.uk
Dr Alex Gusachenko
Biomolecular Sciences Building
University of St Andrews
North Haugh
St Andrews
KY16 9ST
Fife
UK


Related Content:

research@st-andrews
School of Biology

Symbiosis Profile Page
edit og21 details

[source: research@st-andrews]

Recent Publications:

Recent publications


0  (of 0 published available) for og21. (source: University of St Andrews PURE)
Please click title of any item for full details.


[hide]
Moffat, Dr Christopher: Research Fellow

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fax:
room:
email: cm364@st-andrews.ac.uk
Dr Christopher Moffat
Biomolecular Sciences Building
University of St Andrews
North Haugh
St Andrews
KY16 9ST
Fife
UK


Related Content:

research@st-andrews
School of Biology

Symbiosis Profile Page
edit cm364 details

[source: research@st-andrews]

Publications:

Chronic exposure to neonicotinoids increases neuronal vulnerability to mitochondrial dysfunction in the bumblebee (Bombus terrestris). Moffat C, Pacheco J G, Sharp S, Samson A J, Bollan K A, Huang J, Buckland S T, Connolly C N. 2015. FASEB.

5-HT cellular sequestration during chronic exposure delays 5-HT3 receptor resensitization due to its subsequent release. Hothersall J D, Alexander A, Samson A J, Moffat C, Bollan K A, Connolly C N. 2014. Journal of Biological Chemistry.

Prolonged inhibition of 5-HT3 receptors by palonosetron results from irreversible binding rather than inducing receptor internalisation. Hothersall J. D*, Moffat C*, Connolly C N. 2013. British Journal of Pharmacology * Joint first authorship.

Exposure to cholinergic pesticides causes mushroom body neuronal inactivation and deficits in olfactory learning in honeybees. 2013. Palmer M J, Moffat C, Saranzewa N, Harvey J, Wright G A, Connolly C N. Nature Communications.

Exposure to acetylcholinesterase inhibitors alters the physiology and motor function of honeybees. Williamson S M, Moffat C, Gommersall M A E, Saranzewa N, Connolly C N, Wright G A. 2013. Frontiers in Invertebrate Physiology

The microsporidian parasites Nosema ceranae and Nosema apis are widespread in honeybee (Apis mellifera) colonies across Scotland. 2012. Bollan K.A, Hothersall J.D, Moffat C, Durkacz J, Saranzewa N, Wright G.A, Raine N.E, Highet F, Connolly C N. Parisitology Research.

[source: Symbiosis]

Recent Publications:

Recent publications


0  (of 0 published available) for cm364. (source: University of St Andrews PURE)
Please click title of any item for full details.


[hide]
Pearson, Mr Ashley: Technician

tel: 01334 464801
fax:
room:
email: ajp20@st-andrews.ac.uk
Mr Ashley Pearson
Biomedical Sciences Building
University of St Andrews
North Haugh
St Andrews
KY16 9ST
Fife
UK


Related Content:

research@st-andrews
School of Biology
Biomedical Sciences Research Complex
Biology Equality and Diversity Committee

Symbiosis Profile Page
edit ajp20 details
Data could not be retrieved from PURE at this time. (profile)

[source: research@st-andrews]

Recent Publications:

Data could not be retrieved from PURE at this time. (research-outputs/persons)[hide]

 

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